Anti-GPCR G2A antibody (ab116586)
Key features and details
- Rabbit polyclonal to GPCR G2A
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-GPCR G2A antibody
See all GPCR G2A primary antibodies -
Description
Rabbit polyclonal to GPCR G2A -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide against the C-terminal domain of Human GPCRG2A protein (Q9UNW8) conjugated to KLH.
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Positive control
- Human Spleen tissue.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.4
Preservative: 0.1% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab116586 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
Use a concentration of 12 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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Notes |
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IHC-P
Use a concentration of 12 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Target
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Function
Receptor for an unknown ligand. Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May serve as a mechanism for T- and B-cells, and other cell types, to slow their proliferation and repair damaged DNA to ensure proper replication. -
Tissue specificity
Highly expressed in macrophages and hematopoietic tissues rich in lymphocytes, like spleen and thymus. Weakly expressed in heart and lung. In atherosclerotic plaques, expression is observed around the lipid core and at the shoulder region. -
Sequence similarities
Belongs to the G-protein coupled receptor 1 family. -
Cellular localization
Cell membrane. Internalized and accumulated in endosomal compartments. LPC triggers the relocalization from the endosomal compartment to the cell surface. - Information by UniProt
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Database links
- Entrez Gene: 29933 Human
- Omim: 606167 Human
- SwissProt: Q9UNW8 Human
- Unigene: 532504 Human
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Alternative names
- G Protein Coupled Receptor G2A antibody
- G2 accumulation protein antibody
- G2A antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (2)
ab116586 has been referenced in 2 publications.
- Klatt W et al. Expression profiles of proton-sensing G-protein coupled receptors in common skin tumors. Sci Rep 10:15327 (2020). PubMed: 32948783
- Nassios A et al. Expression of Proton-sensing G-Protein-coupled receptors in selected skin tumors. Exp Dermatol N/A:N/A (2018). PubMed: 30339292