Anti-GPCR G2A antibody - C-terminal (ab188942)

Overview

  • Product name
    Anti-GPCR G2A antibody - C-terminal
    See all GPCR G2A primary antibodies
  • Description
    Rabbit polyclonal to GPCR G2A - C-terminal
  • Host species
    Rabbit
  • Specificity
    BLAST analysis of the peptide immunogen showed no homology with other Human proteins, except DNAH8 (50%).
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Hamster, Monkey, Gorilla
  • Immunogen

    Synthetic peptide corresponding to Human GPCR G2A (C terminal). 18 amino acid peptide from C-terminal cytoplasmic domain. NP_037477.1.
    Database link: Q9UNW8

  • Positive control
    • Human lung and Human spleen, red pulp tissues.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.1% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab188942 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 10 µg/ml. Perform enzymatic antigen retrieval before commencing with IHC staining protocol.

Antigen retrieval requires Proteinase K treatment.

Target

  • Function
    Receptor for an unknown ligand. Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May serve as a mechanism for T- and B-cells, and other cell types, to slow their proliferation and repair damaged DNA to ensure proper replication.
  • Tissue specificity
    Highly expressed in macrophages and hematopoietic tissues rich in lymphocytes, like spleen and thymus. Weakly expressed in heart and lung. In atherosclerotic plaques, expression is observed around the lipid core and at the shoulder region.
  • Sequence similarities
    Belongs to the G-protein coupled receptor 1 family.
  • Cellular localization
    Cell membrane. Internalized and accumulated in endosomal compartments. LPC triggers the relocalization from the endosomal compartment to the cell surface.
  • Information by UniProt
  • Database links
  • Alternative names
    • G Protein Coupled Receptor G2A antibody
    • G2 accumulation protein antibody
    • G2A antibody
    • GP132_HUMAN antibody
    • GPR132 antibody
    • Probable G-protein coupled receptor 132 antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human spleen, red pulp tissue labeling GPCR G2A with ab188942 at 10 µg/ml.

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human lung tissue labeling GPCR G2A with ab188942 at 10 µg/ml.

References

ab188942 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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