FunctionReceptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway.
Tissue specificityPredominantly expressed in the pancreas, especially in the islets.
Sequence similaritiesBelongs to the G-protein coupled receptor 1 family.
Left panel: immunofluorescence analysis of MCF-7 cells, using 1/500 ab75312. Right panel: same, after pre-incubation with the immunizing peptide.
References for Anti-GPCR GPR119 antibody (ab75312)
This product has been referenced in:
Little TJ et al. Characterization of duodenal expression and localization of fatty acid-sensing receptors in humans: relationships with body mass index. Am J Physiol Gastrointest Liver Physiol307:G958-67 (2014).
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