Anti-GPCR GPR120 antibody (ab118757)

Overview

  • Product nameAnti-GPCR GPR120 antibody
    See all GPCR GPR120 primary antibodies
  • Description
    Rabbit polyclonal to GPCR GPR120
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog
  • Immunogen

    Synthetic peptide corresponding to a region within internal sequence amino acids 243-292 (VVTHSEITKA SRKRLTVSLA YSESHQIRVS QQDFRLFRTL FLLMVSFFIM) of Human GPCR GPR120.

  • Positive control
    • HepG2 cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab118757 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 42 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionReceptor for medium and long-chain free fatty acid (FAA). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti-inflammatory effects particulary in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1 dependent effect but independent of G(q)/G(11)-coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage-induced tissue inflammation. May mediates the taste of fatty acids.
  • Tissue specificityAbundant expression in the intestinal tract.
  • Sequence similaritiesBelongs to the G-protein coupled receptor 1 family.
  • Post-translational
    modifications
    Phosphorylated. FFA stimulation facilitates phosphorylation.
  • Cellular localizationCell membrane. Colocalized with ARRB2 following DHA treatment.
  • Information by UniProt
  • Database links
  • Alternative names
    • G protein coupled receptor 120 antibody
    • G protein coupled receptor 129 antibody
    • G protein coupled receptor GT01 antibody
    • G protein coupled receptor PGR 4 antibody
    • G protein coupled receptor PGR4 antibody
    • G-protein coupled receptor 120 antibody
    • G-protein coupled receptor 129 antibody
    • G-protein coupled receptor GT01 antibody
    • G-protein coupled receptor PGR4 antibody
    • GPR 120 antibody
    • GPR 129 antibody
    • GPR120 antibody
    • GPR129 antibody
    • GT01 antibody
    • HGNC:19345 antibody
    • MGC119984 antibody
    • O3FA1_HUMAN antibody
    • O3FAR1 antibody
    • Omega-3 fatty acid receptor 1 antibody
    • PGR 4 antibody
    • PGR4 antibody
    see all

Anti-GPCR GPR120 antibody images

  • Anti-GPCR GPR120 antibody (ab118757) at 1 µg/ml + HepG2 cell lysate at 10 µg

    Predicted band size : 42 kDa

References for Anti-GPCR GPR120 antibody (ab118757)

ab118757 has not yet been referenced specifically in any publications.

Product Wall

Application Western blot
Sample Rat Tissue lysate - whole (rat pituitary, mouse LbT2 cell line)
Gel Running Conditions Non-reduced Denaturing (10%)
Loading amount 30 µg
Specification rat pituitary, mouse LbT2 cell line
Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 6% · Temperature: 20°C
Username

Abcam user community

Verified customer

Submitted May 20 2015

Application Western blot
Sample Mouse Cell lysate - whole cell (LbetaT2 gonadotrope cell line)
Gel Running Conditions Non-reduced Denaturing (10% SDS-PAGE)
Loading amount 30 µg
Specification LbetaT2 gonadotrope cell line
Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 6% · Temperature: 20°C
Username

Abcam user community

Verified customer

Submitted May 20 2015

Vielen Dank für Ihre Antwort.
Wie besprochen wurde ab118757 bisher noch nicht in Maus getestet.
Falls Sie dies selbst testen möchten, kann ich Ihnen zurzeit ein spezielles Angebot über einen 100%igen Abreview-Rabatt anbieten. Bei diesem Angeb...

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Vielen Dank für das Telefongespräch gestern.
Ich möchte nochmals betonen wie leid es uns tut, dass ab75313 nicht in der von Ihnen gewünschten Menge lieferbar ist.
Leider haben wir keinen anderen GPCR GPR120 Antikörper, der für Maus getestet i...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"