Overview

  • Product name
  • Description
    Rabbit polyclonal to GPCR GPR120
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to a region within amino acids 1 - 41 of Human GPCR GPR120 (NP_859529).

  • Positive control
    • WB: HeLa cell lysate IHC-P: Human prostate adenocarcinoma

Properties

Applications

Our Abpromise guarantee covers the use of ab97272 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/2000. Predicted molecular weight: 42 kDa.
IHC-P 1/50 - 1/500.

Target

  • Function
    Receptor for medium and long-chain free fatty acid (FAA). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti-inflammatory effects particulary in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1 dependent effect but independent of G(q)/G(11)-coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage-induced tissue inflammation. May mediates the taste of fatty acids.
  • Tissue specificity
    Abundant expression in the intestinal tract.
  • Sequence similarities
    Belongs to the G-protein coupled receptor 1 family.
  • Post-translational
    modifications
    Phosphorylated. FFA stimulation facilitates phosphorylation.
  • Cellular localization
    Cell membrane. Colocalized with ARRB2 following DHA treatment.
  • Information by UniProt
  • Database links
  • Alternative names
    • BMIQ10 antibody
    • FFAR4 antibody
    • Free fatty acid receptor 4 antibody
    • G protein coupled receptor 120 antibody
    • G protein coupled receptor 129 antibody
    • G protein coupled receptor GT01 antibody
    • G protein coupled receptor PGR 4 antibody
    • G protein coupled receptor PGR4 antibody
    • G-protein coupled receptor 120 antibody
    • G-protein coupled receptor 129 antibody
    • G-protein coupled receptor GT01 antibody
    • G-protein coupled receptor PGR4 antibody
    • GPR 120 antibody
    • GPR 129 antibody
    • GPR120 antibody
    • GPR129 antibody
    • GT01 antibody
    • HGNC:19345 antibody
    • MGC119984 antibody
    • O3FA1_HUMAN antibody
    • O3FAR1 antibody
    • Omega-3 fatty acid receptor 1 antibody
    • PGR 4 antibody
    • PGR4 antibody
    see all

Images

  • Anti-GPCR GPR120 antibody (ab97272) at 1/2000 dilution + HeLa whole cell lysate at 30 µg

    Predicted band size : 42 kDa
  • ab97272, at a 1/500 dilution, staining GPCR GPR120 in paraffin embedded Human prostate adenocarcinoma by Immunohistochemical analysis (20X magnification).
  • ab97272, at a 1/500 dilution, staining GPCR GPR120 in paraffin embedded Human prostate adenocarcinoma by Immunohistochemical analysis (40X magnification).

References

This product has been referenced in:
  • Yamada H  et al. Eicosapentaenoic acid shows anti-inflammatory effect via GPR120 in 3T3-L1 adipocytes and attenuates adipose tissue inflammation in diet-induced obese mice. Nutr Metab (Lond) 14:33 (2017). WB ; Mouse . Read more (PubMed: 28503189) »
  • Lager S  et al. Expression and localization of the omega-3 fatty acid receptor GPR120 in human term placenta. Placenta 35:523-5 (2014). IHC . Read more (PubMed: 24844436) »

See all 2 Publications for this product

Customer reviews and Q&As

Thank you for your inquiry.

The exact immunogen sequence is proprietary information and I also do not have access to it.

But I would like to confirm that I blasted the sequence of the amino acid range of 1 -41and found only one simi...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up