Overview

  • Product name
  • Description
    Rabbit polyclonal to GPCR GPR124
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, from the N terminal extracellular domain of Human GPCR GPR124 (NP_116166.9).

  • Positive control
    • Human colon carcinoma tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab117105 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 11 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    Endothelial receptor that acts as an essential regulator of CNS angiogenesis. Required for normal endothelial cell sprouting and migration in the forebrain and neural tube.
  • Tissue specificity
    Expressed in endothelial cells (at protein level). Abundantly expressed in tumor vessels, heart, placenta, ovary, small intestine, and colon.
  • Sequence similarities
    Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
    Contains 1 GPS domain.
    Contains 1 Ig-like (immunoglobulin-like) domain.
    Contains 4 LRR (leucine-rich) repeats.
    Contains 1 LRRCT domain.
    Contains 1 LRRNT domain.
  • Domain
    Binds to DLG1 through its PDZ-binding motif.
  • Cellular localization
    Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • DKFZp434C211 antibody
    • DKFZp434J0911 antibody
    • FLJ14390 antibody
    • G protein coupled receptor 124 antibody
    • G-protein coupled receptor 124 antibody
    • GP124_HUMAN antibody
    • GPR 124 antibody
    • Gpr124 antibody
    • KIAA1531 antibody
    • TEM 5 antibody
    • TEM5 antibody
    • Tumor endothelial marker 5 antibody
    • Tumor endothelial marker 5 precursor antibody
    see all

Images

  • ab117105 at 11µg/ml staining GPCR GPR124 in Formalin-fixed, Paraffin-embedded Human Colon carcinoma tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

References

ab117105 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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