Anti-GPCR GPR126 antibody - C-terminal (ab188895)

Overview

  • Product name
    Anti-GPCR GPR126 antibody - C-terminal
    See all GPCR GPR126 primary antibodies
  • Description
    Rabbit polyclonal to GPCR GPR126 - C-terminal
  • Host species
    Rabbit
  • Specificity
    BLAST analysis of the peptide immunogen showed no homology with other human proteins.
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Gorilla, Common marmoset
  • Immunogen

    Synthetic peptide within Human GPCR GPR126 (C terminal). The exact sequence is proprietary. 16 amino acid peptide.
    Database link: Q86SQ4

  • Positive control
    • Human brain, neurons and glia tissue.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.1% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab188895 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 3 - 5 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Function
    Orphan receptor. May be required for normal differentiation of promyelinating Schwann cells and for normal myelination of axons. Signals probably through G-proteins to transiently elevate cAMP levels.
  • Tissue specificity
    Expressed in placenta and to a lower extent in pancreas and liver. Detected in aortic endothelial cells but not in skin microvascular endothelial cells.
  • Sequence similarities
    Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
    Contains 1 CUB domain.
    Contains 1 GPS domain.
    Contains 1 pentaxin domain.
  • Post-translational
    modifications
    Proteolytically cleaved into 2 conserved sites: one in the GPS domain (S1 site) and the other in the middle of the extracellular domain (S2 site). The proteolytic cleavage at S1 site generates an extracellular subunit and a seven-transmembrane subunit. Furin is involved in the cleavage of the S2 site generating a soluble fragment. Processing at the GPS domain occurred independent of and probably prior to the cleavage at the S2 site.
  • Cellular localization
    Cell membrane. Detected on the cell surface of activated but not resting umbilical vein.
  • Information by UniProt
  • Database links
  • Alternative names
    • adhesion G protein coupled receptor G6 antibody
    • APG1 antibody
    • Developmentally regulated G protein coupled receptor antibody
    • Developmentally regulated G-protein-coupled receptor antibody
    • dj287g14.2 antibody
    • DREG antibody
    • G protein coupled receptor 126 antibody
    • G-protein coupled receptor 126 antibody
    • GP126_HUMAN antibody
    • GPR126 antibody
    • HBV PreS1 transactivated protein 2 antibody
    • HBV PreS1-transactivated protein 2 antibody
    • LCCS9 antibody
    • OTTHUMP00000017320 antibody
    • OTTHUMP00000237093 antibody
    • OTTHUMP00000237094 antibody
    • OTTHUMP00000237115 antibody
    • PR126 antibody
    • Probable G protein coupled receptor 126 [Precursor] antibody
    • Probable G protein coupled receptor 126 antibody
    • Probable G-protein coupled receptor 126 [Precursor] antibody
    • Probable G-protein coupled receptor 126 antibody
    • PS1TP2 antibody
    • Vascular inducible G protein coupled receptor antibody
    • Vascular inducible G protein-coupled receptor antibody
    • VIGR antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human brain, neurons and glia tissue labeling GPCR GPR126 with ab188895 at 5 µg/ml.

References

ab188895 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab188895.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up