Anti-GPCR GPR17 antibody (ab75553)
Key features and details
- Rabbit polyclonal to GPCR GPR17
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-GPCR GPR17 antibody
See all GPCR GPR17 primary antibodies -
Description
Rabbit polyclonal to GPCR GPR17 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide derived from an internal sequence of human GPCR GPR17
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Positive control
- Extracts from LOVO cells
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, PBS
Without Mg2+ and Ca2+ -
Concentration information loading...
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Purity
Immunogen affinity purified -
Purification notes
The antibody was affinity purified from rabbit antiserum by affinity chromatography using epitope immunogen. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab75553 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/1000. Predicted molecular weight: 41 kDa.
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Notes |
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WB
1/500 - 1/1000. Predicted molecular weight: 41 kDa. |
Target
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Function
Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia. -
Tissue specificity
Expressed in brain, kidney, heart and umbilical vein endothelial cells. Highest level in brain. -
Sequence similarities
Belongs to the G-protein coupled receptor 1 family. -
Cellular localization
Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 2840 Human
- Omim: 603071 Human
- SwissProt: Q13304 Human
- Unigene: 46453 Human
- Unigene: 688940 Human
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Alternative names
- DKFZp686M18273 antibody
- G protein coupled receptor 17 antibody
- G-protein coupled receptor 17 antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab75553 has been referenced in 1 publication.
- Luo Q et al. Cangrelor ameliorates CLP-induced pulmonary injury in sepsis by inhibiting GPR17. Eur J Med Res 26:70 (2021). PubMed: 34229761