Anti-GPCR GPR3 antibody - N-terminal (ab188596)

Overview

  • Product name
    Anti-GPCR GPR3 antibody - N-terminal
    See all GPCR GPR3 primary antibodies
  • Description
    Rabbit polyclonal to GPCR GPR3 - N-terminal
  • Host species
    Rabbit
  • Specificity
    BLAST analysis of the peptide immunogen showed no homology with other Human proteins, except CASKIN2 (53%), INPPL1 (47%).
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rabbit, Horse, Cow, Monkey, Gorilla, Common marmoset
  • Immunogen

    Synthetic peptide corresponding to Human GPCR GPR3 (N terminal). (17 amino acid peptide from extracellular domain; NP_005272.1)
    Database link: P46089

  • Positive control
    • Human brain tissue

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.1% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab188596 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Has a potential role in modulating a number of brain functions, including behavioral responses to stress (By similarity), amyloid-beta peptide generation in neurons and neurite outgrowth (By similarity). Maintains also meiotic arrest in oocytes.
  • Tissue specificity
    Expressed predominantly in the central nervous system, and at low levels in the lung, kidney, testis, ovary and eye. Highly expressed in regions of the brain implicated in the Alzheimer disease.
  • Sequence similarities
    Belongs to the G-protein coupled receptor 1 family.
  • Cellular localization
    Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • ACCA antibody
    • ACCA orphan receptor antibody
    • Adenylate cyclase constitutive activator antibody
    • G protein coupled receptor 3 antibody
    • G-protein coupled receptor 3 antibody
    • Gpr3 antibody
    • GPR3_HUMAN antibody
    • Probable G protein coupled receptor GPR3 antibody
    see all

Images

  • Immunohistochemical analysis of formalin fixed, paraffin embedded Human brain labeling GPCR GPR3 with ab188596 at 10 µg/ml.

References

ab188596 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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