Overview

  • Product name
  • Description
    Rabbit polyclonal to GPCR GPR37
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region from the N-terminal extracellular domain of Human GPCR GPR37.

  • Positive control
    • Human brain cortex tissue.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at -80°C.
  • Storage buffer
    Preservative: 0.1% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Protein A purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab115902 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 3 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    Orphan receptor. May have a unique functional role in the central nervous system.
  • Tissue specificity
    Expressed in brain and spinal cord, and at lower levels in testis, placenta and liver, but no detectable expression observed in any other tissue. When overexpressed in cells, tends to become insoluble and unfolded. Accumulation of the unfolded protein may lead to dopaminergic neuronal death in juvenile Parkinson disease (PDJ).
  • Sequence similarities
    Belongs to the G-protein coupled receptor 1 family.
  • Post-translational
    modifications
    Ubiquitinated by PARK2 in the presence of UBE2E1 and UBE2L3 in the endoplasmic reticulum. The unfolded form is specifically ubiquitinated by SYVN1, which promotes its proteasomal degradation and prevents neuronal cell death.
  • Cellular localization
    Cell membrane. Endoplasmic reticulum membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • EDNRBL antibody
    • Endothelin B receptor like protein 1 antibody
    • Endothelin B receptor-like protein 1 antibody
    • Endothelin receptor type B like antibody
    • ETBR LP 1 antibody
    • ETBR-LP-1 antibody
    • ETBRLP1 antibody
    • G protein coupled receptor 37 antibody
    • G protein coupled receptor 37 endothelin receptor type B like antibody
    • Gpr37 antibody
    • GPR37_HUMAN antibody
    • hET(B)R LP antibody
    • hET(B)RLP antibody
    • PAELR antibody
    • Parkin associated endothelin receptor like receptor antibody
    • Parkin-associated endothelin receptor-like receptor antibody
    • Probable G protein coupled receptor 37 antibody
    • Probable G-protein coupled receptor 37 antibody
    see all

Anti-GPCR GPR37 antibody images

  • ab115902, at 3 µg/ml, staining GPCR GPR37 in Formalin-fixed, Paraffin-embedded Human brain cortex tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

References for Anti-GPCR GPR37 antibody (ab115902)

ab115902 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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