The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-GPCR GPR40 antibody (ab32889)
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
Free fatty acid receptor 1
G protein coupled receptor 40
G-protein coupled receptor 40
FunctionReceptor for medium and long chain saturated and unsaturated fatty acids. Binding of the ligand increase intracellular calcium concentration and amplify glucose-stimulated insulin secretion. The activity of this receptor is mediated by G-proteins that activate phospholipase C. Seems to act through a G(q) and G(i)-mediated pathway.
Tissue specificityExpressed abundantly in pancreatic beta cells.
Sequence similaritiesBelongs to the G-protein coupled receptor 1 family.