Overview

  • Product name
  • Description
    Rabbit polyclonal to GPCR GPR81
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within C-terminal amino acids 286-316 of Human GPCR GPR81 (NP_115943.1).

  • Positive control
    • 293 cell lysate

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • Storage buffer
    Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    Purified through a Protein A column, followed by peptide affinity purification.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab124010 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 39 kDa.

Target

  • Function
    Acts as a receptor for L-lactate and mediates its anti-lipolytic effect through a G(i)-protein-mediated pathway.
  • Tissue specificity
    Expressed abundantly in brown and white fat. It also detectable at lower levels in liver, kidney, skeletal muscle, brain and pituitary. Not detected in frontal, temporal and occipital lobes of the cortex, basal forebrain, caudate nucleus, nucleus accumbens and hippocampus.
  • Sequence similarities
    Belongs to the G-protein coupled receptor 1 family.
  • Cellular localization
    Cell membrane.
  • Information by UniProt
  • Database links
  • Form
    G protein-coupled receptors (GPCRs, or GPRs), such as GPR81, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.
  • Alternative names
    • FKSG80 antibody
    • FKSG80 protein antibody
    • G protein coupled receptor 104 antibody
    • G protein coupled receptor 81 antibody
    • G protein coupled receptor GPR81 antibody
    • G-protein coupled receptor 104 antibody
    • G-protein coupled receptor 81 antibody
    • GPR 104 antibody
    • GPR 81 antibody
    • GPR104 antibody
    • GPR81 antibody
    • GPR81_HUMAN antibody
    • HCA1 antibody
    • HCAR1 antibody
    • hydroxy-carboxylic acid receptor 1 antibody
    • Hydroxycarboxylic acid receptor 1 antibody
    • LACR1 antibody
    • lactate receptor 1 antibody
    • Putative chemokine receptor antibody
    • T cell activation G protein coupled receptor antibody
    • TA GPCR antibody
    see all

Images

  • Anti-GPCR GPR81 antibody (ab124010) at 1/100 dilution + 293 cell line lysate at 35 µg

    Predicted band size: 39 kDa

References

This product has been referenced in:
  • Li X  et al. Upregulation of lactate-inducible snail protein suppresses oncogene-mediated senescence through p16INK4ainactivation. J Exp Clin Cancer Res 37:39 (2018). Read more (PubMed: 29482580) »
  • Feng J  et al. Tumor cell-derived lactate induces TAZ-dependent upregulation of PD-L1 through GPR81 in human lung cancer cells. Oncogene 36:5829-5839 (2017). Read more (PubMed: 28604752) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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