Overview

  • Product name
  • Description
    Rabbit polyclonal to GPCR MRGX2
  • Specificity
    BLAST analysis of the peptide immunogen showed no homology with other Human proteins, except MRGPRX1 (71%), MRGPRX4 (64%), MRGPRX3 (57%).
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Chimpanzee, Monkey, Gorilla, Common marmoset, Orangutan
  • Immunogen

    Synthetic peptide within Human GPCR MRGX2 (extracellular). The exact sequence is proprietary. synthetic 14 amino acid peptide from 2nd extracellular domain of human GPCR MRGX2. NP_473371.1.
    Database link: Q96LB1

  • Positive control
    • Human spinal cord (dorsal root ganglion) tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab188767 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 2 - 4 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Function
    Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca(2+) but had no effect on basal or forskolin-stimulated cAMP levels, suggesting that this receptor is G(q)-coupled.
  • Tissue specificity
    Has a limited expression profile, both peripheral and within the central nervous system, with highest levels in dorsal root ganglion.
  • Sequence similarities
    Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
  • Cellular localization
    Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • G protein coupled receptor MRGX 2 antibody
    • G protein coupled receptor MRGX2 antibody
    • Mas related G protein coupled receptor member X2 antibody
    • Mas related gene MRGX 2 antibody
    • Mas related gene MRGX2 antibody
    • MAS related GPR member X2 antibody
    • Mas-related G-protein coupled receptor member X antibody
    • Mas-related G-protein coupled receptor member X2 antibody
    • MRGPRX 2 antibody
    • MRGPRX2 antibody
    • MRGX 2 antibody
    • MRGX2 antibody
    • MRGX2_HUMAN antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human spinal cord (dorsal root ganglion) tissue labeling GPCR MRGX2 with ab188767 at 4µg/ml. 

     

References

ab188767 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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