• Product nameAnti-GPD1L antibody
    See all GPD1L primary antibodies
  • Description
    Mouse polyclonal to GPD1L
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Rat, Human
  • Immunogen

    Full length human GDP1L protein (NP_055956)

  • Positive control
    • Rat brain lysate. GPD1L transfected 293T cell lysate.



Our Abpromise guarantee covers the use of ab68799 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 36 kDa (predicted molecular weight: 38 kDa).


  • FunctionPlay a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L.
  • Tissue specificityMost highly expressed in heart tissue, with lower levels in the skeletal muscle, kidney, lung and other organs.
  • Involvement in diseaseDefects in GPD1L are the cause of Brugada syndrome type 2 (BRS2) [MIM:611777]. BRS2 is an autosomal dominant tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset.
    Defects in GPD1L are a cause of sudden infant death syndrome (SIDS) [MIM:272120]. SIDS is the sudden death of an infant younger than 1 year that remains unexplained after a thorough case investigation, including performance of a complete autopsy, examination of the death scene, and review of clinical history. Pathophysiologic mechanisms for SIDS may include respiratory dysfunction, cardiac dysrhythmias, cardiorespiratory instability, and inborn errors of metabolism, but definitive pathogenic mechanisms precipitating an infant sudden death remain elusive.
  • Sequence similaritiesBelongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
  • Cellular localizationCytoplasm. Localized to the region of the plasma membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • 2210409H23Rik antibody
    • D9Ertd660e antibody
    • Glycerol 3 phosphate dehydrogenase 1 like antibody
    • Glycerol 3 phosphate dehydrogenase 1 like protein antibody
    • Glycerol-3-phosphate dehydrogenase 1-like protein antibody
    • GPD 1L antibody
    • GPD1-L antibody
    • gpd1l antibody
    • GPD1L_HUMAN antibody
    • KIAA0089 antibody
    • RGD1560123 antibody
    see all

Anti-GPD1L antibody images

  • Anti-GPD1L antibody (ab68799) at 1/500 dilution + Rat brain lysate at 25 µg

    Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

    Predicted band size : 38 kDa
    Observed band size : 36 kDa (why is the actual band size different from the predicted?)
  • All lanes : Anti-GPD1L antibody (ab68799) at 1/500 dilution

    Lane 1 : GPD1L transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

    Predicted band size : 38 kDa
    Observed band size : 36 kDa (why is the actual band size different from the predicted?)

References for Anti-GPD1L antibody (ab68799)

ab68799 has not yet been referenced specifically in any publications.

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