• Product nameAnti-GPD1L antibody
    See all GPD1L primary antibodies
  • Description
    Rabbit polyclonal to GPD1L
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Zebrafish
  • Immunogen

    Synthetic peptide within residues: ELEKEMLNGQ KLQGPQTSAE VYRILKQKGL LDKFPLFTAV YQICYESRPV , corresponding to internal sequence amino acids 288-337 of Human GPD1L (NP_055956)

  • Positive control
    • Fetal muscle lysate.



Our Abpromise guarantee covers the use of ab83406 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Detects a band of approximately 38 kDa (predicted molecular weight: 38 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
ELISA Use at an assay dependent concentration.

ELISA titre using peptide based assay: 1/312500.


  • FunctionPlay a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L.
  • Tissue specificityMost highly expressed in heart tissue, with lower levels in the skeletal muscle, kidney, lung and other organs.
  • Involvement in diseaseDefects in GPD1L are the cause of Brugada syndrome type 2 (BRS2) [MIM:611777]. BRS2 is an autosomal dominant tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset.
    Defects in GPD1L are a cause of sudden infant death syndrome (SIDS) [MIM:272120]. SIDS is the sudden death of an infant younger than 1 year that remains unexplained after a thorough case investigation, including performance of a complete autopsy, examination of the death scene, and review of clinical history. Pathophysiologic mechanisms for SIDS may include respiratory dysfunction, cardiac dysrhythmias, cardiorespiratory instability, and inborn errors of metabolism, but definitive pathogenic mechanisms precipitating an infant sudden death remain elusive.
  • Sequence similaritiesBelongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
  • Cellular localizationCytoplasm. Localized to the region of the plasma membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • 2210409H23Rik antibody
    • D9Ertd660e antibody
    • Glycerol 3 phosphate dehydrogenase 1 like antibody
    • Glycerol 3 phosphate dehydrogenase 1 like protein antibody
    • Glycerol-3-phosphate dehydrogenase 1-like protein antibody
    • GPD 1L antibody
    • GPD1-L antibody
    • gpd1l antibody
    • GPD1L_HUMAN antibody
    • KIAA0089 antibody
    • RGD1560123 antibody
    see all

Anti-GPD1L antibody images

  • Anti-GPD1L antibody (ab83406) at 1 µg/ml (in 5% skim milk / PBS buffer) + Fetal muscle lysate at 10 µg

    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 38 kDa
    Observed band size : 38 kDa

References for Anti-GPD1L antibody (ab83406)

ab83406 has not yet been referenced specifically in any publications.

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