The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 45 kDa (predicted molecular weight: 44 kDa).
Use a concentration of 3.75 µg/ml.
FunctionReceptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase.
Tissue specificityExpressed in the ileocecum, thyroid gland, pituitary gland, salivary gland, adrenal gland, testis, ovary and brain.
Involvement in diseaseHypogonadotropic hypogonadism 3 with or without anosmia
Sequence similaritiesBelongs to the G-protein coupled receptor 1 family.