FunctionGuanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction.
Tissue specificityExpressed in intestinal cells.
Sequence similaritiesBelongs to the GPSM family. Contains 4 GoLoco domains. Contains 9 TPR repeats.
DomainThe GoLoco domains mediate interaction with G(i/o) alpha (By similarity). The GoLoco domains are essential for the GDI activity toward G(i/o) alpha.
Post-translational modificationsPhosphorylation regulates interaction with G(i/o) alpha.