Plays an important role in spindle pole orientation. Interacts and contributes to the functional activity of G(i) alpha proteins. Acts to stabilize the apical complex during neuroblast divisions.
Involvement in disease
Defects in GPSM2 are the cause of deafness autosomal recessive type 82 (DFNB82) [MIM:613557]. DFNB82 is a form of non-syndromic deafness characterized by prelingual, bilateral, severe, sensorineural hearing loss. There are no symptoms of vestibular dysfunction.
Belongs to the GPSM family. Contains 4 GoLoco domains. Contains 8 TPR repeats.
Cytoplasm. Cytoplasm > cell cortex. Localizes in the cytoplasm in the interphase and at cell periphery in the metaphase.
G protein signalling modulator 2 (AGS3 like C. elegans) antibody
G protein signalling modulator 2 antibody
G-protein-signaling modulator 2 antibody
LGN protein antibody
Mosaic protein LGN antibody
Western blot - GPSM2 antibody (ab109594)
All lanes : Anti-GPSM2 antibody (ab109594) at 0.1 µg/ml
Lane 1 : HeLa whole cell lysate at 50 µg Lane 2 : HeLa whole cell lysate at 15 µg Lane 3 : HeLa whole cell lysate at 5 µg Lane 4 : 293T whole cell lysate at 50 µg
Developed using the ECL technique
Predicted band size : 77 kDa
Exposure time : 3 minutes
Immunoprecipitation - GPSM2 antibody (ab109594)
Detection of GPSM2 by Western Blot of Immunprecipitate.
ab109594 at 1µg/ml staining GPSM2 in HeLa whole cell lysate immunoprecipitated using ab109594 at 6µg/mg lysate (1 mg/IP; 20% of IP loaded/lane).
Detection: Chemiluminescence with exposure time of 30 seconds.