Overview

  • Product name
  • Description
    Rabbit polyclonal to GPSM2
  • Tested applications
    Suitable for: IPmore details
    Unsuitable for: WB
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Cow, Chimpanzee, Orangutan
  • Immunogen

    Synthetic peptide corresponding to a region between amino acids 450-500 of Human GPSM2 (AAH27732.1).

  • Positive control
    • HeLa whole cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab110147 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP Use at 2-5 µg/mg of lysate.
  • Application notes
    Is unsuitable for WB.
  • Target

    • Function
      Plays an important role in spindle pole orientation. Interacts and contributes to the functional activity of G(i) alpha proteins. Acts to stabilize the apical complex during neuroblast divisions.
    • Tissue specificity
      Ubiquitously expressed.
    • Involvement in disease
      Defects in GPSM2 are the cause of deafness autosomal recessive type 82 (DFNB82) [MIM:613557]. DFNB82 is a form of non-syndromic deafness characterized by prelingual, bilateral, severe, sensorineural hearing loss. There are no symptoms of vestibular dysfunction.
    • Sequence similarities
      Belongs to the GPSM family.
      Contains 4 GoLoco domains.
      Contains 8 TPR repeats.
    • Cellular localization
      Cytoplasm. Cytoplasm > cell cortex. Localizes in the cytoplasm in the interphase and at cell periphery in the metaphase.
    • Information by UniProt
    • Database links
    • Alternative names
      • DFNB82 antibody
      • G protein signalling modulator 2 (AGS3 like C. elegans) antibody
      • G protein signalling modulator 2 antibody
      • G-protein-signaling modulator 2 antibody
      • Gpsm2 antibody
      • GPSM2_HUMAN antibody
      • HGNC:29501 antibody
      • LGN antibody
      • LGN protein antibody
      • Mosaic protein LGN antibody
      • Pins antibody
      see all

    Images

    • Detection of GPSM2 in Immunoprecipitates of HeLa whole cell lysates (1 mg for IP, 20% of IP loaded) using ab110147 at 6 µg/mg lysate for IP (Lane 1). For WB detection an anti-GPSM2 antibody which recognizes a downstream epitope was used at 1 µg/ml. Lane 2 represents control IgG IP. Detection: Chemiluminescence with an exposure time of 30 seconds.

    References

    ab110147 has not yet been referenced specifically in any publications.

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