The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at 2-5 µg/mg of lysate.
Application notesIs unsuitable for WB.
FunctionPlays an important role in spindle pole orientation. Interacts and contributes to the functional activity of G(i) alpha proteins. Acts to stabilize the apical complex during neuroblast divisions.
Tissue specificityUbiquitously expressed.
Involvement in diseaseDefects in GPSM2 are the cause of deafness autosomal recessive type 82 (DFNB82) [MIM:613557]. DFNB82 is a form of non-syndromic deafness characterized by prelingual, bilateral, severe, sensorineural hearing loss. There are no symptoms of vestibular dysfunction.
Sequence similaritiesBelongs to the GPSM family. Contains 4 GoLoco domains. Contains 8 TPR repeats.
Cellular localizationCytoplasm. Cytoplasm > cell cortex. Localizes in the cytoplasm in the interphase and at cell periphery in the metaphase.
G protein signalling modulator 2 (AGS3 like C. elegans) antibody
G protein signalling modulator 2 antibody
G-protein-signaling modulator 2 antibody
LGN protein antibody
Mosaic protein LGN antibody
Anti-GPSM2 antibody images
Immunoprecipitation - GPSM2 antibody (ab110147)
Detection of GPSM2 in Immunoprecipitates of HeLa whole cell lysates (1 mg for IP, 20% of IP loaded) using ab110147 at 6 µg/mg lysate for IP (Lane 1). For WB detection an anti-GPSM2 antibody which recognizes a downstream epitope was used at 1 µg/ml. Lane 2 represents control IgG IP. Detection: Chemiluminescence with an exposure time of 30 seconds.
References for Anti-GPSM2 antibody (ab110147)
has not yet been referenced specifically in any publications.
Publishing research using ab110147? Please let us know so that we can cite the reference in this datasheet.
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