Overview

  • Product name
    GR 125743
  • Description
    5-HT1B/1D antagonist
  • Biological description
    5-HT1B / 1D antagonist (pKi = 8.5), often used in tritiated form as a radiolabelled probe. Shows approx. 100-fold selectivity over other 5-HT receptors and shows CNS and oral activity.
  • Purity
    > 99%

Properties

References

This product has been referenced in:
  • Millan MJ  et al. Specific labelling of serotonin 5-HT(1B) receptors in rat frontal cortex with the novel, phenylpiperazine derivative, [3H]GR125,743. A pharmacological characterization. Pharmacol Biochem Behav 71:589-98 (2002). Read more (PubMed: 11888550) »
  • Audinot V  et al. Binding profile of the novel 5-HT1B/1D receptor antagonist, [3H]GR 125,743, in guinea-pig brain: a comparison with [3H]5-carboxamidotryptamine. Eur J Pharmacol 327:247-56 (1997). Read more (PubMed: 9200567) »
  • Doménech T  et al. Characterization of human serotonin 1D and 1B receptors using [3H]-GR-125743, a novel radiolabelled serotonin 5HT1D/1B receptor antagonist. Naunyn Schmiedebergs Arch Pharmacol 356:328-34 (1997). Read more (PubMed: 9303569) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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