Overview

  • Product name
    GR 127935 hydrochloride
  • Description
    Potent, selective 5-HT1B/1D receptor antagonist
  • Biological description
    Potent and selective 5-HT1B/1D receptor antagonist (pKi = 8.5 for both 5-HT1D in rat and 5-HT1D in guinea pig). 100-fold selectivity over 5-HT1A, 5-HT1E, and 5-HT2C. Displays centrally mediated effects upon systemic administration.
  • Purity
    > 97%

Properties

References

This product has been referenced in:
  • Knobelman DA  et al. Genetic regulation of extracellular serotonin by 5-hydroxytryptamine(1A) and 5-hydroxytryptamine(1B) autoreceptors in different brain regions of the mouse. J Pharmacol Exp Ther 298:1083-91 (2001). Read more (PubMed: 11504805) »
  • Yu XJ  et al. The 5-HT1D receptor antagonist GR-127,935 prevents inhibitory effects of sumatriptan but not CP-122,288 and 5-CT on neurogenic plasma extravasation within guinea pig dura mater. Neuropharmacology 36:83-91 (1997). Read more (PubMed: 9144644) »
  • Lucas JJ  et al. 5-Hydroxytryptamine1B receptors modulate the effect of cocaine on c-fos expression: converging evidence using 5-hydroxytryptamine1B knockout mice and the 5-hydroxytryptamine1B/1D antagonist GR127935. Mol Pharmacol 51:755-63 (1997). Read more (PubMed: 9145913) »
  • Skingle M  et al. GR127935: a potent and selective 5-HT1D receptor antagonist. Behav Brain Res 73:157-61 (1996). Read more (PubMed: 8788495) »
  • Hidiroglou M  et al. Effects of level of dietary sulfur on the growth performance and blood mineral profile of sheep fed urea-supplemented corn silage. Int J Vitam Nutr Res 47:284-91 (1977). Read more (PubMed: 914464) »

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