Biological description5-HT1B/1D agonist. 10-fold higher selectivity over 5-HT1A. Displays centrally mediated effects upon systemic administration.
Storage instructionsShipped at Room Temperature. Store at -20°C. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 100 mM and in ethanol to 10 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
O'Neill MF & Sanger GJ GR46611 potentiates 5-HT1A receptor-mediated locomotor activity in the guinea pig. Eur J Pharmacol370:85-92 (1999).
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Gobert A et al. Simultaneous quantification of serotonin, dopamine and noradrenaline levels in single frontal cortex dialysates of freely-moving rats reveals a complex pattern of reciprocal auto- and heteroreceptor-mediated control of release. Neuroscience84:413-29 (1998).
Read more (PubMed: 9539213) »