Overview

  • Product name
    GR 55562 dihydrochloride
  • Description
    Selective 5-HT1B / 5-HT1D receptor antagonist
  • Biological description
    Selective, competitive 5-HT1B/ 5-HT1D receptor antagonist (pKi values are 7.4 and 6.2, respectively). Inhibits 5-HT evoked contraction in pulmonary resistance arteries (pEC10 = 7.26).
  • Purity
    > 99%

Properties

References

This product has been referenced in:
  • Maassen VanDenBrink A  et al. Human isolated coronary artery contraction to sumatriptan characterised by the selective 5-HT1B/1D receptor antagonist GR55562. Pharmacol Toxicol 86:287-90 (2000). Read more (PubMed: 10895993) »
  • Nilsson T  et al. Contractile 5-HT1B receptors in human cerebral arteries: pharmacological characterization and localization with immunocytochemistry. Br J Pharmacol 128:1133-40 (1999). Read more (PubMed: 10578124) »
  • Morecroft I & MacLean MR 5-hydroxytryptamine receptors mediating vasoconstriction and vasodilation in perinatal and adult rabbit small pulmonary arteries. Br J Pharmacol 125:69-78 (1998). Read more (PubMed: 9776346) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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