Anti-Gram Negative Endotoxin antibody [11-222.4] (ab41201)

Overview

  • Product name
    Anti-Gram Negative Endotoxin antibody [11-222.4]
  • Description
    Mouse monoclonal [11-222.4] to Gram Negative Endotoxin
  • Tested applications
    Suitable for: ELISAmore details
  • Species reactivity
    Sh. sonnei, S. typhimurium, S. marcescens, P. mirabilis, P. vulgaris, A. calcoaceticus
  • Immunogen

    Escherichia coli O:111 B4 J5 cells

  • General notes


    This antibody may be used in immunoassays to detect and quantitate gram negative endotoxin or cells that express endotoxin.

    Abcam is committed to meeting high standards of ethical manufacturing and has decided to discontinue this product by June 2019 as it has been generated by the ascites method. We are sorry for any inconvenience this may cause. 

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    Preservative: None
    Constituents: PBS, pH 7.4
  • Concentration information loading...
  • Purity
    Protein G purified
  • Primary antibody notes
    This antibody may be used in immunoassays to detect and quantitate gram negative endotoxin or cells that express endotoxin.
  • Clonality
    Monoclonal
  • Clone number
    11-222.4
  • Isotype
    IgG2a
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab41201 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/1600.

Target

  • Relevance
    Endotoxins are part of the outer membrane of the cell wall of gram negative bacteria. Endotoxins are invariably associated with gram negative bacteria whether the organisms are pathogens or not. Although the term "endotoxin" is occasionally used to refer to any cell associated bacterial toxin, it is properly reserved to refer to the lipopolysaccharide complex associated with the outer membrane of gram-negative bacteria such as E. coli, Salmonella, Shigella, Pseudomonas, Neisseria, Haemophilus, and other leading pathogens. The biological activity of endotoxins are associated with lipopolysaccharide (LPS). Toxicity is associated with the lipid component (Lipid A) and immunogenicity is associated with the polysaccharide components. The cell wall antigens (O antigens) of gram negative bacteria are components of LPS. LPS elicits a variety of inflammatory responses in an animal. Because it activates complement by the alternative (properdin) pathway, it is often part of the pathology of gram negative bacterial infections.
  • Cellular localization
    Cell Membrane
  • Alternative names
    • E coli LPS antibody

References

ab41201 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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