Anti-Granzyme A antibody [GA6] (ab10870)
Key features and details
- Mouse monoclonal [GA6] to Granzyme A
- Suitable for: IHC-P, IHC-FoFr, WB
- Reacts with: Human
- Isotype: IgG1
Get better batch-to-batch reproducibility with a recombinant antibody
- Research with confidence – consistent and reproducible results with every batch
- Long-term and scalable supply – powered by recombinant technology for fast production
- Success from the first experiment – confirmed specificity through extensive validation
- Ethical standards compliant – production is animal-free
Overview
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Product name
Anti-Granzyme A antibody [GA6]
See all Granzyme A primary antibodies -
Description
Mouse monoclonal [GA6] to Granzyme A -
Host species
Mouse -
Tested applications
Suitable for: IHC-P, IHC-FoFr, WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
Recombinant full length protein corresponding to Human Granzyme A.
Database link: P12544 -
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
Preservative: 0.09% Sodium azide
Constituent: PBS -
Concentration information loading...
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Purity
Protein A purified -
Purification notes
Purified IgG prepared by affinity chromatography from tissue culture supernatant. -
Clonality
Monoclonal -
Clone number
GA6 -
Myeloma
Sp2/0 -
Isotype
IgG1 -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab10870 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P | (1) |
Use at an assay dependent concentration.
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IHC-FoFr |
Use at an assay dependent concentration. PubMed: 19827750
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WB |
Use at an assay dependent concentration. Predicted molecular weight: 29 kDa.
Recognises a 60kD disulphide-linked homodimeric protein. |
Notes |
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IHC-P
Use at an assay dependent concentration. |
IHC-FoFr
Use at an assay dependent concentration. PubMed: 19827750 |
WB
Use at an assay dependent concentration. Predicted molecular weight: 29 kDa. Recognises a 60kD disulphide-linked homodimeric protein. |
Target
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Function
This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Involved in apoptosis. -
Sequence similarities
Belongs to the peptidase S1 family. Granzyme subfamily.
Contains 1 peptidase S1 domain. -
Cellular localization
Secreted. Cytoplasmic granule. - Information by UniProt
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Database links
- Entrez Gene: 3001 Human
- Omim: 140050 Human
- SwissProt: P12544 Human
- Unigene: 90708 Human
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Alternative names
- CTL tryptase antibody
- CTLA3 antibody
- Cytolytic t cell and natural killer cell specific trypsin like serine protease antibody
see all
Protocols
Datasheets and documents
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Datasheet download
References (4)
ab10870 has been referenced in 4 publications.
- Papalampros A et al. Unique Spatial Immune Profiling in Pancreatic Ductal Adenocarcinoma with Enrichment of Exhausted and Senescent T Cells and Diffused CD47-SIRPa Expression. Cancers (Basel) 12:N/A (2020). PubMed: 32645996
- Wu F et al. Molecular subtyping reveals immune alterations in IDH wild-type lower-grade diffuse glioma. J Pathol 251:272-283 (2020). PubMed: 32418210
- Li H et al. Glucocorticoid Receptor and Sequential P53 Activation by Dexamethasone Mediates Apoptosis and Cell Cycle Arrest of Osteoblastic MC3T3-E1 Cells. PLoS One 7:e37030 (2012). WB ; Mouse . PubMed: 22719835
- Hirono S et al. Molecular markers associated with lymph node metastasis in pancreatic ductal adenocarcinoma by genome-wide expression profiling. Cancer Sci : (2009). IHC-FoFr ; Human . PubMed: 19817750