Overview

  • Product name
  • Description
    Goat polyclonal to GRB7
  • Tested applications
    Suitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide: ELDLSPPHLSSSPE, corresponding to amino acids 2-15 of Human GRB 7.

  • Positive control
    • A431 lysate
  • General notes
    Principal Names - GRB7; growth factor receptor-bound protein 7 Official Gene Symbol - GRB7 GenBank Accession Number – NP_005301 LocusLink ID - 2886 Gene Ontology terms - oncogenesis; SH3/SH2 adaptor protein; EGF receptor signalling pathway

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, 0.5mg/ml Tris, pH 7.3
  • Concentration information loading...
  • Purity
    IgG fraction
  • Purification notes
    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab2630 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA
WB
  • Application notes
    ELISA: 1/32000.
    WB: Use at a concentration of 1 - 3 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Interacts with the cytoplasmic domain of the epidermal growth factor receptor which is then inhibited. The interaction is mediated by the SH2 domain. Also binds to ERBB2.
    • Sequence similarities
      Belongs to the GRB7/10/14 family.
      Contains 1 PH domain.
      Contains 1 Ras-associating domain.
      Contains 1 SH2 domain.
    • Post-translational
      modifications
      Phosphorylated on tyrosine residues.
    • Information by UniProt
    • Database links
    • Alternative names
      • B47 antibody
      • Epidermal growth factor receptor GRB 7 antibody
      • Epidermal growth factor receptor GRB-7 antibody
      • GRB7 adapter protein antibody
      • GRB7 antibody
      • GRB7_HUMAN antibody
      • Growth factor receptor bound protein 7 antibody
      • Growth factor receptor-bound protein 7 antibody
      • OTTHUMP00000164349 antibody
      • OTTHUMP00000164350 antibody
      • OTTHUMP00000164351 antibody
      • OTTHUMP00000164352 antibody
      see all

    References

    This product has been referenced in:
    • Tsichlaki E & FitzHarris G Nucleus downscaling in mouse embryos is regulated by cooperative developmental and geometric programs. Sci Rep 6:28040 (2016). Read more (PubMed: 27320842) »

    See 1 Publication for this product

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab2630.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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