Overview

  • Product nameAnti-GRHPR antibody [9G2]
    See all GRHPR primary antibodies
  • Description
    Mouse monoclonal [9G2] to GRHPR
  • Tested applicationsSuitable for: WB, Flow Cytmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length protein of Human GRHPR produced in HEK293T cells (NP_036335).

  • Positive control
    • HEK293T cells transfected with GRHPR
  • General notesConcentration: 0.5~1.0 mg/ml (Lot Dependent)

Properties

Applications

Our Abpromise guarantee covers the use of ab119081 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/2000. Predicted molecular weight: 36 kDa.
Flow Cyt 1/100. ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

Target

  • FunctionEnzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate.
  • Tissue specificityUbiquitous. Most abundantly expressed in the liver.
  • Involvement in diseaseDefects in GRHPR are the cause of hyperoxaluria primary type 2 (HP2) [MIM:260000]; also known as primary hyperoxaluria type II (PH2). HP2 is a disorder where the main clinical manifestation is calcium oxalate nephrolithiasis though chronic as well as terminal renal insufficiency has been described. It is characterized by an elevated urinary excretion of oxalate and L-glycerate.
  • Sequence similaritiesBelongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
  • Information by UniProt
  • Database links
  • Alternative names
    • GLXR antibody
    • glycerate 2 dehydrogenase antibody
    • GLYD antibody
    • Glyoxylate reductase/hydroxypyruvate reductase antibody
    • Grhpr antibody
    • GRHPR_HUMAN antibody
    • OTTHUMP00000021379 antibody
    • OTTHUMP00000021380 antibody
    • OTTHUMP00000046131 antibody
    • PH 2 antibody
    • PH2 antibody
    • Primary hyperoxaluria type 2 antibody
    see all

Anti-GRHPR antibody [9G2] images

  • All lanes : Anti-GRHPR antibody [9G2] (ab119081) at 1/2000 dilution

    Lane 1 : HEK293T cells transfected with pCMV6-ENTRY control
    Lane 2 : HEK293T cells transfected with pCMV6-ENTRY GRHPR

    Lysates/proteins at 5 µg per lane.


    Predicted band size : 36 kDa
    HEK293T cell lysates were generated from transient transfection of the cDNA clone (RC200963)
  • HEK293T cells transfected with either RC200963 overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by ab119081 at a dilution of 1/100, and then analyzed by flow cytometry.

References for Anti-GRHPR antibody [9G2] (ab119081)

ab119081 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab119081.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"