Overview

  • Product name
    Anti-GRHPR antibody
  • Description
    Rabbit polyclonal to GRHPR
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Rat, Cow
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 1-328 of Human GRHPR (Uniprot ID Q9UBQ7).

  • Positive control
    • A431, H1299, HeLa, HepG2, MOLT4 and Raji cell lines; 293T and Mouse liver whole cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab155604 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 36 kDa.

Target

  • Function
    Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate.
  • Tissue specificity
    Ubiquitous. Most abundantly expressed in the liver.
  • Involvement in disease
    Defects in GRHPR are the cause of hyperoxaluria primary type 2 (HP2) [MIM:260000]; also known as primary hyperoxaluria type II (PH2). HP2 is a disorder where the main clinical manifestation is calcium oxalate nephrolithiasis though chronic as well as terminal renal insufficiency has been described. It is characterized by an elevated urinary excretion of oxalate and L-glycerate.
  • Sequence similarities
    Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
  • Information by UniProt
  • Database links
  • Alternative names
    • GLXR antibody
    • glycerate 2 dehydrogenase antibody
    • GLYD antibody
    • Glyoxylate reductase/hydroxypyruvate reductase antibody
    • Grhpr antibody
    • GRHPR_HUMAN antibody
    • OTTHUMP00000021379 antibody
    • OTTHUMP00000021380 antibody
    • OTTHUMP00000046131 antibody
    • PH 2 antibody
    • PH2 antibody
    • Primary hyperoxaluria type 2 antibody
    see all

Images

  • Anti-GRHPR antibody (ab155604) at 1/1000 dilution + 293T whole cell lysate at 30 µg

    Predicted band size: 36 kDa



    10% SDS PAGE
  • Anti-GRHPR antibody (ab155604) at 1/10000 dilution + Mouse liver whole cell lysate at 20 µg

    Predicted band size: 36 kDa



    10% SDS PAGE

References

ab155604 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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