The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/2000. Predicted molecular weight: 36 kDa.
1/100. ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
FunctionEnzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate.
Tissue specificityUbiquitous. Most abundantly expressed in the liver.
Involvement in diseaseDefects in GRHPR are the cause of hyperoxaluria primary type 2 (HP2) [MIM:260000]; also known as primary hyperoxaluria type II (PH2). HP2 is a disorder where the main clinical manifestation is calcium oxalate nephrolithiasis though chronic as well as terminal renal insufficiency has been described. It is characterized by an elevated urinary excretion of oxalate and L-glycerate.
Sequence similaritiesBelongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
HEK293T cells transfected with either RC200963 overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by ab119081 at a dilution of 1/100, and then analyzed by flow cytometry.
References for Anti-GRHPR antibody [OTI9G2] (ab119081)
has not yet been referenced specifically in any publications.
Publishing research using ab119081? Please let us know so that we can cite the reference in this datasheet.
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