Overview

  • Product name
  • Description
    Rabbit polyclonal to GRIK1
  • Tested applications
    Suitable for: WB, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Rat, Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide corresponding to 16 internal sequence amino acids of Human GRIK1.

  • Positive control
    • Human Adrenal tissue; Rat brain tissue lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab118891 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 104 kDa.
ELISA Use at an assay dependent concentration.
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.
  • Tissue specificity
    Most abundant in the cerebellum and the suprachiasmatic nuclei (SCN) of the hypothalamus.
  • Sequence similarities
    Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK1 subfamily.
  • Cellular localization
    Cell membrane. Cell junction > synapse > postsynaptic cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • EAA3 antibody
    • EEA3 antibody
    • Excitatory amino acid receptor 3 antibody
    • GLR5 antibody
    • GluR-5 antibody
    • GluR5 antibody
    • GluR6 antibody
    • GluR7 antibody
    • Glutamate receptor 5 antibody
    • Glutamate receptor antibody
    • Glutamate receptor ionotropic kainate 1 antibody
    • GRIK1 antibody
    • GRIK1_HUMAN antibody
    • Human glutamate receptor GLUR5 antibody
    • ionotropic kainate 1 antibody
    • OTTHUMP00000096569 antibody
    see all

Images

  • ab118891 at 5 µg/ml staining GRIK1 in Formalin-fixed, Paraffin-embedded Human Adrenal tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.
  • Lane 1 : Anti-GRIK1 antibody (ab118891) at 0.5 µg/ml
    Lane 2 : Anti-GRIK1 antibody (ab118891) at 1 µg/ml

    Lane 1 : Rat Brain Tissue Lysate
    Lane 2 : Rat Brain Tissue Lysate


    Predicted band size : 104 kDa

References

ab118891 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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