Overview

Description

  • Nature
    Synthetic

Associated products

Specifications

Our Abpromise guarantee covers the use of ab115358 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-GRIK1 antibody (ab67317)

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: 0.02% Sodium azide
    Constituent: PBS

General Info

  • Alternative names
    • EAA3
    • EEA3
    • Excitatory amino acid receptor 3
    • GLR5
    • GluR-5
    • GluR5
    • GluR6
    • GluR7
    • Glutamate receptor
    • Glutamate receptor 5
    • Glutamate receptor ionotropic kainate 1
    • GRIK1
    • GRIK1_HUMAN
    • Human glutamate receptor GLUR5
    • ionotropic kainate 1
    • OTTHUMP00000096569
    see all
  • Function
    Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.
  • Tissue specificity
    Most abundant in the cerebellum and the suprachiasmatic nuclei (SCN) of the hypothalamus.
  • Sequence similarities
    Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK1 subfamily.
  • Cellular localization
    Cell membrane. Cell junction > synapse > postsynaptic cell membrane.
  • Information by UniProt

References

ab115358 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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