• Product nameAnti-GRIK2 antibody
    See all GRIK2 primary antibodies
  • Description
    Rabbit polyclonal to GRIK2
  • Specificityab28697 recognises Glutamate receptor, ionotropic kainate 2 precursor (GRIK2).
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow, Dog, Chimpanzee
  • Immunogen

    Synthetic peptide derived from a region between 156-205 of human GRIK2. (Note: the exact amino acid sequence is proprietary).

  • Positive control
    • Jurkat Cell Lysate


  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • PurityProtein A purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas


Our Abpromise guarantee covers the use of ab28697 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 2.5 µg/ml. Detects a band of approximately 88 kDa (predicted molecular weight: 103 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
ELISA 1/62500.


  • FunctionIonotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2.
  • Tissue specificityExpression is higher in cerebellum than in cerebral cortex.
  • Involvement in diseaseDefects in GRIK2 are the cause of mental retardation autosomal recessive type 6 (MRT6) [MIM:611092]. It is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. In contrast to syndromic or specific mental retardation which also present with associated physical, neurological and/or psychiatric manifestations, intellectual deficiency is the only primary symptom of non-syndromic mental retardation. MRT6 patients display mild to severe mental retardation and psychomotor development delay in early childhood. Patients do not have neurologic problems, congenital malformations, or facial dysmorphism. Body height, weight, and head circumference are normal.
  • Sequence similaritiesBelongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK2 subfamily.
  • Post-translational
    Sumoylation mediates kainate receptor-mediated endocytosis and regulates synaptic transmission. Sumoylation is enhanced by PIAS3 and desumoylated by SENP1.
    Ubiquitinated. Ubiquitination regulates the GRIK2 levels at the synapse by leading kainate receptor degradation through proteasome.
  • Cellular localizationCell membrane. Cell junction > synapse > postsynaptic cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • bA487F5.1 antibody
    • EAA4 antibody
    • Excitatory amino acid receptor 4 antibody
    • GLR 6 antibody
    • GLR6 antibody
    • GluK2 antibody
    • GLUK6 antibody
    • GLUR 6 antibody
    • GluR-6 antibody
    • GluR6 antibody
    • Glutamate receptor 6 antibody
    • Glutamate receptor antibody
    • glutamate receptor form A antibody
    • glutamate receptor form B antibody
    • glutamate receptor form C antibody
    • glutamate receptor form D antibody
    • glutamate receptor form E antibody
    • Glutamate receptor ionotropic kainate 2 antibody
    • GRIK 2 antibody
    • GRIK2 antibody
    • GRIK2 protein antibody
    • GRIK2_HUMAN antibody
    • ionotropic kainate 2 antibody
    • MRT6 antibody
    see all

Anti-GRIK2 antibody images

References for Anti-GRIK2 antibody (ab28697)

ab28697 has not yet been referenced specifically in any publications.

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