• Product nameAnti-GRIK2 antibody
    See all GRIK2 primary antibodies
  • Description
    Rabbit polyclonal to GRIK2
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    A 13 amino acid peptide from near the carboxy terminus of human GRIK2.

  • Positive control
    • human brain tissue lysate



Our Abpromise guarantee covers the use of ab67318 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 - 1 µg/ml. Detects a band of approximately 103 kDa (predicted molecular weight: 103 kDa).


  • FunctionIonotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2.
  • Tissue specificityExpression is higher in cerebellum than in cerebral cortex.
  • Involvement in diseaseDefects in GRIK2 are the cause of mental retardation autosomal recessive type 6 (MRT6) [MIM:611092]. It is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. In contrast to syndromic or specific mental retardation which also present with associated physical, neurological and/or psychiatric manifestations, intellectual deficiency is the only primary symptom of non-syndromic mental retardation. MRT6 patients display mild to severe mental retardation and psychomotor development delay in early childhood. Patients do not have neurologic problems, congenital malformations, or facial dysmorphism. Body height, weight, and head circumference are normal.
  • Sequence similaritiesBelongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK2 subfamily.
  • Post-translational
    Sumoylation mediates kainate receptor-mediated endocytosis and regulates synaptic transmission. Sumoylation is enhanced by PIAS3 and desumoylated by SENP1.
    Ubiquitinated. Ubiquitination regulates the GRIK2 levels at the synapse by leading kainate receptor degradation through proteasome.
  • Cellular localizationCell membrane. Cell junction > synapse > postsynaptic cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • bA487F5.1 antibody
    • EAA4 antibody
    • Excitatory amino acid receptor 4 antibody
    • GLR 6 antibody
    • GLR6 antibody
    • GluK2 antibody
    • GLUK6 antibody
    • GLUR 6 antibody
    • GluR-6 antibody
    • GluR6 antibody
    • Glutamate receptor 6 antibody
    • Glutamate receptor antibody
    • glutamate receptor form A antibody
    • glutamate receptor form B antibody
    • glutamate receptor form C antibody
    • glutamate receptor form D antibody
    • glutamate receptor form E antibody
    • Glutamate receptor ionotropic kainate 2 antibody
    • GRIK 2 antibody
    • GRIK2 antibody
    • GRIK2 protein antibody
    • GRIK2_HUMAN antibody
    • ionotropic kainate 2 antibody
    • MRT6 antibody
    see all

Anti-GRIK2 antibody images

  • Lane 1 : Anti-GRIK2 antibody (ab67318) at 0.5 µg/ml
    Lane 2 : Anti-GRIK2 antibody (ab67318) at 1 µg/ml

    Lane 1 : human brain tissue lysate
    Lane 2 : human brain tissue lysate

    Lysates/proteins at 15 µg per lane.

    Predicted band size : 103 kDa
    Observed band size : 103 kDa
    Additional bands at : 70 kDa. We are unsure as to the identity of these extra bands.

References for Anti-GRIK2 antibody (ab67318)

ab67318 has not yet been referenced specifically in any publications.

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