Anti-GRIM19 antibody (ab186848)
Key features and details
- Rabbit polyclonal to GRIM19
- Suitable for: WB
- Reacts with: Mouse, Human
- Isotype: IgG
Overview
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Product name
Anti-GRIM19 antibody
See all GRIM19 primary antibodies -
Description
Rabbit polyclonal to GRIM19 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Mouse, Human -
Immunogen
Recombinant fragment corresponding to Human GRIM19 (C terminal). C-terminal 93AA
Database link: Q9P0J0 -
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol, 49% PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab186848 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/2000. Predicted molecular weight: 17 kDa.
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Notes |
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WB
1/500 - 1/2000. Predicted molecular weight: 17 kDa. |
Target
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Function
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes. -
Tissue specificity
Widely expressed, with highest expression in heart, skeletal muscle, liver, kidney and placenta. In intestinal mucosa, down-regulated in areas involved in Crohn disease and ulcerative colitis. -
Involvement in disease
Defects in NDUFA13 may be a cause of susceptibility to Hurthle cell thyroid carcinoma (HCTC) [MIM:607464]. Hurthle cell thyroid carcinoma accounts for approximately 3% of all thyroid cancers. Although they are classified as variants of follicular neoplasms, they are more often multifocal and somewhat more aggressive and are less likely to take up iodine than are other follicular neoplasms. -
Sequence similarities
Belongs to the complex I NDUFA13 subunit family. -
Developmental stage
Expressed in numerous fetal tissues. -
Cellular localization
Mitochondrion inner membrane. Nucleus. May be translocated into the nucleus upon IFN/RA treatment. - Information by UniProt
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Database links
- Entrez Gene: 51079 Human
- Entrez Gene: 67184 Mouse
- Omim: 609435 Human
- SwissProt: Q9P0J0 Human
- SwissProt: Q9ERS2 Mouse
- Unigene: 534453 Human
- Unigene: 21162 Mouse
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Alternative names
- 2700054G14Rik antibody
- AU022060 antibody
- B16.6 antibody
see all
Images
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All lanes : Anti-GRIM19 antibody (ab186848) at 1/500 dilution
Lane 1 : MCF7 cell extract
Lane 2 : K562 cell extract
Lane 3 : 293T cell extract
Lane 4 : 3T3L1 cell extract
Lane 5 : M21 cell extract
Lane 6 : SK-HEP-1 cell extract
Lane 7 : Mouse kidney extract
Lane 8 : Mouse heart extract
Lane 9 : Mouse liver extract
Predicted band size: 17 kDa
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab186848 has been referenced in 1 publication.
- Wang Y et al. Expressions and clinical significances of STAT3 and Grim19 in epithelial ovarian cancer. 3 Biotech 10:246 (2020). PubMed: 32411570