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Antisense expression of GRIM 19 (Genes associated with Retinoid-IFN-induced Mortality) confers a strong resistance against IFN/RA-induced death by reducing the intracellular levels of GRIM 19 protein. Overexpression of GRIM 19 enhances cell death in response to IFN/RA. GRIM 19 is primarily a nuclear protein whose expression is induced by the IFN/RA combination. These data indicate that GRIM 19 is a novel cell death-regulatory molecule.
Our Abpromise guarantee covers the use of ab3449 in the following tested applications.
|WB||1/500 - 1/1000. Detects a band of approximately 16 kDa (predicted molecular weight: 16 kDa).|