Overview

  • Product nameAnti-GRK1 antibody [EPR2039(2)]
    See all GRK1 primary antibodies
  • Description
    Rabbit monoclonal [EPR2039(2)] to GRK1
  • Tested applicationsSuitable for: WBmore details
    Unsuitable for: Flow Cyt,ICC,IHC-P or IP
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    A synthetic peptide corresponding to residues in Human GRK1.

  • Positive control
    • Y79 and JAR cell lysates.
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

Properties

Applications

Our Abpromise guarantee covers the use of ab108502 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Detects a band of approximately 60 kDa (predicted molecular weight: 60 kDa).
  • Application notesIs unsuitable for Flow Cyt,ICC,IHC-P or IP.
  • Target

    • FunctionRetina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade. This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination.
    • Tissue specificityRetinal-specific. Expressed in rods and cones cells.
    • Involvement in diseaseNight blindness, congenital stationary, Oguchi type 2
    • Sequence similaritiesBelongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
      Contains 1 AGC-kinase C-terminal domain.
      Contains 1 protein kinase domain.
      Contains 1 RGS domain.
    • Post-translational
      modifications
      Autophosphorylated, Ser-21 is a minor site of autophosphorylation compared to Ser-491 and Thr-492 (By similarity). Phosphorylation at Ser-21 is regulated by light and activated by cAMP.
      Farnesylation is required for full activity.
    • Cellular localizationMembrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • EC=2.7.11.14 antibody
      • G protein-coupled receptor kinase 1 antibody
      • GPRK1 antibody
      • Grk1 antibody
      • Rhodopsin kinase antibody
      • RHOK antibody
      • RK antibody
      • RK_HUMAN antibody
      see all

    Anti-GRK1 antibody [EPR2039(2)] images

    • All lanes : Anti-GRK1 antibody [EPR2039(2)] (ab108502) at 1/1000 dilution

      Lane 1 : Y79 cell lysate
      Lane 2 : JAR cell lysate

      Lysates/proteins at 10 µg per lane.


      Predicted band size : 60 kDa
      Observed band size : 60 kDa

    References for Anti-GRK1 antibody [EPR2039(2)] (ab108502)

    ab108502 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"