Overview

  • Product name
  • Description
    Goat polyclonal to GRK2
  • Tested applications
    Suitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Hamster, Cow, Dog, Chimpanzee, Macaque monkey
  • Immunogen

    Synthetic peptide:

    C-RDAYREAQQLVQR

    , corresponding to internal sequence amino acids 648-660 of Human GRK2.

  • Positive control
    • Human lysates of Burkitt's lymphoma cell line Daudi

Properties

Applications

Our Abpromise guarantee covers the use of ab47999 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA
WB
  • Application notes
    ELISA: detection limit dilution 1/16000.
    WB: Use at a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 75 kDa (predicted molecular weight: 80 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.
    • Tissue specificity
      Expressed in peripheral blood leukocytes.
    • Sequence similarities
      Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
      Contains 1 AGC-kinase C-terminal domain.
      Contains 1 PH domain.
      Contains 1 protein kinase domain.
      Contains 1 RGS domain.
    • Information by UniProt
    • Database links
    • Alternative names
      • ADRBK1 antibody
      • Adrenergic beta receptor kinase 1 antibody
      • ARBK1_HUMAN antibody
      • BARK antibody
      • BARK1 antibody
      • Beta adrenergic receptor kinase 1 antibody
      • Beta ARK 1 antibody
      • Beta ARK1 antibody
      • Beta-adrenergic receptor kinase 1 antibody
      • Beta-ARK-1 antibody
      • FLJ16718 antibody
      • G protein coupled receptor kinase 2 antibody
      • G-protein coupled receptor kinase 2 antibody
      • GRK2 antibody
      see all

    Images

    References

    ab47999 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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