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Storage instructions Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage buffer Preservative: 0.09% Sodium Azide
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Purity Protein G purified
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/100 - 1/500. Detects a band of approximately 66 kDa (predicted molecular weight: 66 kDa).
1/50 - 1/100.
Function Specifically phosphorylates the activated forms of G protein-coupled receptors.
Tissue specificity Widely expressed.
Sequence similarities Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. Contains 1 AGC-kinase C-terminal domain. Contains 1 protein kinase domain. Contains 1 RGS domain.
Post-translational modifications It is uncertain whether palmitoylation is on Cys-561 and/or Cys-562 and/or Cys-565.
Cellular localization Membrane.
Information by UniProt
Form There are 2 isoforms produced by alternative splicing.
G protein coupled receptor kinase 6 antibody
G protein coupled receptor kinase GRK6 antibody
Anti-GRK6 antibody - Carboxyterminal end images
Western blot - GRK6 antibody (ab38291)
All lanes : Anti-GRK6 antibody - Carboxyterminal end (ab38291) at 1/100 dilution Lane 1 : HeLa cell lysate. Lane 2 : Mouse heart tissue lysate. Secondary HRP-anti-rabbit. Developed using the ECL technique Predicted band size : 66 kDa Observed band size : 66 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - GRK6 antibody (ab38291)
ab38291 (1/50) staining human cancer tissue by immunohistochemistry, formalin-fixed, paraffin-embedded tissue. The breast carcinoma tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.
References for Anti-GRK6 antibody - Carboxyterminal end (ab38291)
This product has been referenced in:
et al. Kinome-wide RNAi studies in human multiple myeloma identify vulnerable kinase targets, including a lymphoid-restricted kinase, GRK6. Blood 115:1594-604 (2010).
Read more (PubMed: 19996089) »
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"