Recombinant Anti-GRK6 antibody [EPR2046(2)] (ab109302)
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR2046(2)] to GRK6
- Suitable for: WB
- Reacts with: Human
Related conjugates and formulations
Overview
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Product name
Anti-GRK6 antibody [EPR2046(2)]
See all GRK6 primary antibodies -
Description
Rabbit monoclonal [EPR2046(2)] to GRK6 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details
Unsuitable for: Flow Cyt,IHC-P or IP -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse -
Immunogen
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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Positive control
- U937 cell lysate, Ramos cell lysate, Jurkat cell lysate, K562 cell lysate.
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General notes
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
Rat: We have preliminary internal testing data to indicate this antibody may not react with this species. Please contact us for more information.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
Storage buffer
pH: 7.20
Preservative: 0.05% Sodium azide
Constituents: 0.1% BSA, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 50% Tissue culture supernatant -
Concentration information loading...
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Purity
Protein A purified -
Clonality
Monoclonal -
Clone number
EPR2046(2) -
Isotype
IgG -
Research areas
Associated products
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Alternative Versions
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Isotype control
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Positive Controls
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab109302 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/1000 - 1/10000. Predicted molecular weight: 66 kDa.
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Notes |
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WB
1/1000 - 1/10000. Predicted molecular weight: 66 kDa. |
Target
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Function
Specifically phosphorylates the activated forms of G protein-coupled receptors. -
Tissue specificity
Widely expressed. -
Sequence similarities
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
Contains 1 AGC-kinase C-terminal domain.
Contains 1 protein kinase domain.
Contains 1 RGS domain. -
Post-translational
modificationsIt is uncertain whether palmitoylation is on Cys-561 and/or Cys-562 and/or Cys-565. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 2870 Human
- Entrez Gene: 26385 Mouse
- Omim: 600869 Human
- SwissProt: P43250 Human
- SwissProt: O70293 Mouse
- Unigene: 235116 Human
- Unigene: 10193 Mouse
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Form
There are 2 isoforms produced by alternative splicing. -
Alternative names
- FLJ32135 antibody
- G protein coupled receptor kinase 6 antibody
- G protein coupled receptor kinase GRK6 antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (2)
ab109302 has been referenced in 2 publications.
- Acharya S et al. β-Arrestin1 and GPCR kinase2 play permissive roles in Src-mediated endocytosis of α4β2 nicotinic ACh receptors. Br J Pharmacol 178:3498-3516 (2021). PubMed: 33844281
- Hara S et al. Serine 129 phosphorylation of membrane-associated a-synuclein modulates dopamine transporter function in a G protein-coupled receptor kinase-dependent manner. Mol Biol Cell 24:1649-60, S1-3 (2013). WB ; Human . PubMed: 23576548