Recombinant
RabMAb

Anti-Growth Hormone antibody [EPR11048(B)] (ab157456)

Overview

  • Product name
    Anti-Growth Hormone antibody [EPR11048(B)]
    See all Growth Hormone primary antibodies
  • Description
    Rabbit monoclonal [EPR11048(B)] to Growth Hormone
  • Host species
    Rabbit
  • Specificity
    ab157456 is predicted to cross-react with GH2.
  • Tested applications
    Suitable for: WB, IHC-Pmore details
    Unsuitable for: Flow Cyt
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide, corresponding to residues in Human Growth Hormone (Uniprot: P01241).

  • Positive control
    • Human placenta cell lysate; Human pituitary gland and placenta tissues.
  • General notes

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab157456 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/5000. Predicted molecular weight: 25 kDa.
IHC-P 1/250 - 1/500. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
  • Application notes
    Is unsuitable for Flow Cyt.
  • Target

    • Function
      Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
    • Involvement in disease
      Defects in GH1 are a cause of growth hormone deficiency isolated type 1A (IGHD1A) [MIM:262400]; also known as pituitary dwarfism I. IGHD1A is an autosomal recessive deficiency of GH which causes short stature. IGHD1A patients have an absence of GH with severe dwarfism and often develop anti-GH antibodies when given exogenous GH.
      Defects in GH1 are a cause of growth hormone deficiency isolated type 1B (IGHD1B) [MIM:612781]; also known as dwarfism of Sindh. IGHD1B is an autosomal recessive deficiency of GH which causes short stature. IGHD1B patients have low but detectable levels of GH. Dwarfism is less severe than in IGHD1A and patients usually respond well to exogenous GH.
      Defects in GH1 are the cause of Kowarski syndrome (KWKS) [MIM:262650]; also known as pituitary dwarfism VI.
      Defects in GH1 are a cause of growth hormone deficiency isolated type 2 (IGHD2) [MIM:173100]. IGHD2 is an autosomal dominant deficiency of GH which causes short stature. Clinical severity is variable. Patients have a positive response and immunologic tolerance to growth hormone therapy.
    • Sequence similarities
      Belongs to the somatotropin/prolactin family.
    • Cellular localization
      Secreted.
    • Information by UniProt
    • Database links
    • Alternative names
      • gH antibody
      • GH-N antibody
      • GH1 antibody
      • GHB5 antibody
      • GHN antibody
      • Growth hormone 1 antibody
      • Growth hormone antibody
      • Growth hormone B5 antibody
      • Growth hormone, normal antibody
      • Growth hormone, pituitary antibody
      • HG1 antibody
      • hGH-N antibody
      • IGHD1B antibody
      • Pituitary growth hormone antibody
      • RNGHGP antibody
      • SOMA_HUMAN antibody
      • Somatotropin antibody
      see all

    Images

    • ab157456 showing -ve staining in Human normal tonsil.
    • ab157456 showing -ve staining in Human normal pancreas.
    • ab157456 showing -ve staining in Human normal kidney.
    • Anti-Growth Hormone antibody [EPR11048(B)] (ab157456) at 1/1000 dilution + Human placenta cell lysate at 10 µg

      Secondary
      Goat anti-rabbit HRP at 1/2000 dilution

      Predicted band size: 25 kDa

    • Immunohistochemical analysis of Paraffin-embedded Human pituitary gland tissue labeling Human Growth Hormone with ab157456 at 1/250 dilution.
    • Immunohistochemical analysis of Paraffin-embedded Human placenta tissue labeling Human Growth Hormone with ab157456 at 1/250 dilution

    References

    ab157456 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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