Overview

  • Product name
  • Description
    Rabbit polyclonal to GRXCR1
  • Tested applications
    Suitable for: IHC-P, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    antigen sequence: GVKYKVSAGQ ALFNNLTKVL QQPSTDLEFD RVVIYTTCLR VVRTTFERCE LVRKIFQNHR VKFEEKNIAL NGEYGK, corresponding to amino acids 108-183 of Human GRXCR1.

  • Positive control
    • Human nasopharynx tissue.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    pH: 7.20
    Preservative: 0.02% Sodium azide
    Constituents: 59% PBS, 40% Glycerol
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab122670 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF Use a concentration of 1 - 4 µg/ml.

Recommend PFA Fixation and Triton X-100 treatment

Target

  • Function
    May play a role in actin filament architecture in developing stereocilia of sensory cells.
  • Tissue specificity
    Expressed at low levels in adult lung, brain and duodenum with moderate levels in testis. Highly expressed in fetal cochlea.
  • Involvement in disease
    Defects in GRXCR1 are the cause of deafness autosomal recessive type 25 (DFNB25) [MIM:613285]. DFNB25 is characterized by moderate to severe or profound hearing loss which is progressive in some individuals but not in others. Speech development is impaired in some but not all affected individuals and vestibular dysfunction is observed in some affected individuals.
  • Sequence similarities
    Belongs to the GRXCR1 family.
    Contains 1 glutaredoxin domain.
  • Cellular localization
    Cell projection > stereocilium. Cell projection > microvillus. Cell projection > kinocilium. In the inner ear, localized to stereocilia, apical microvilli of sensory cells and kinocilia.
  • Information by UniProt
  • Database links
  • Alternative names
    • DFNB25 antibody
    • Glutaredoxin domain-containing cysteine-rich protein 1 antibody
    • Glutaredoxin, cysteine rich 1 antibody
    • GRCR1_HUMAN antibody
    • Grxcr1 antibody
    see all

Anti-GRXCR1 antibody images

  • Immunofluorescent staining of Human cell line U-2 OS shows positivity in nucleus but not nucleoli and cell junctions. Recommended concentration of ab122670 1-4 µg/ml. Cells treated with PFA/Triton X-100.
  • ab122670, at 1/50 dilution, staining GRXCR1 in paraffin-embedded Human nasopharynx tissue by Immunohistochemistry.

References for Anti-GRXCR1 antibody (ab122670)

ab122670 has not yet been referenced specifically in any publications.

Product Wall

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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