Overview

  • Product name
  • Description
    Rabbit polyclonal to GSDMB
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human GSDMB aa 21-194.

  • Positive control
    • HeLa whole cell lysate.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 20% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab103980 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 47 kDa.

Target

  • Function
    The N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores (PubMed:27281216). The physiological relevance of this observation is unknown.
  • Tissue specificity
    In the gastrointestinal tract, expressed in proliferating cells, including in the basal cell layer of esophagus and in isthmus/neck of stomach.
  • Sequence similarities
    Belongs to the gasdermin family.
  • Domain
    Intramolecular interactions between N- and C-terminal domains may be important for autoinhibition in the absence of activation signal. The intrinsic pyroptosis-inducing activity is carried by the N-terminal domain.
  • Cellular localization
    Cytoplasm. Cytoplasm, cytosol. Cell membrane. Vesicular localization in the apical region of gastric chief cells and colonic surface mucous cells, and the basal region of neuroendocrine cells.
  • Information by UniProt
  • Database links
  • Form
    There are 5 isoforms produced by alternative splicing.
  • Alternative names
    • 123 antibody
    • 156 antibody
    • Gasdermin B antibody
    • Gasdermin like protein antibody
    • Gasdermin-B antibody
    • Gasdermin-like protein antibody
    • GSDMB antibody
    • GSDMB_HUMAN antibody
    • GSDML antibody
    • PP4052 antibody
    • PRO2521 antibody
    see all

Images

  • Anti-GSDMB antibody (ab103980) at 1/1000 dilution + HeLa whole cell lysate at 30 µg

    Predicted band size : 47 kDa
    10% SDS-PAGE.

References

ab103980 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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