• Product name
    Anti-GSK3 beta antibody [6C2]
    See all GSK3 beta primary antibodies
  • Description
    Mouse monoclonal [6C2] to GSK3 beta
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Recombinant full length, active, human GSK3 beta protein.

  • Positive control
    • HeLa cell lysate.


Our Abpromise guarantee covers the use of ab73271 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/2500. Detects a band of approximately 43 kDa (predicted molecular weight: 47 kDa).


  • Function
    Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin. Phosphorylates SNAI1. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Phosphorylates MACF1 and this phosphorylation inhibits the binding of MACF1 to microtubules which is critical for its role in bulge stem cell migration and skin wound repair.
  • Tissue specificity
    Expressed in testis, thymus, prostate and ovary and weakly expressed in lung, brain and kidney.
  • Sequence similarities
    Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.
    Contains 1 protein kinase domain.
  • Post-translational
    Phosphorylated by AKT1 and ILK1. Activated by phosphorylation at Tyr-216.
  • Cellular localization
    Cytoplasm. Nucleus. Cell membrane. The phosphorylated form shows localization to cytoplasm and cell membrane. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosophorylated form to the cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Glycogen Synthase Kinase 3 Beta antibody
    • Glycogen synthase kinase-3 beta antibody
    • GSK 3 beta antibody
    • GSK-3 beta antibody
    • GSK3B antibody
    • GSK3B_HUMAN antibody
    • GSK3beta isoform antibody
    • Serine/threonine-protein kinase GSK3B antibody
    see all


  • All lanes : Anti-GSK3 beta antibody [6C2] (ab73271) at 1/1000 dilution

    Lane 1 : Cell lysates prepared from Hela cells at 10 µg
    Lane 2 : Cell lysates prepared from Hela cells at 20 µg
    Lane 3 : Cell lysates prepared from Hela cells at 40 µg

    Predicted band size : 47 kDa


This product has been referenced in:
  • Yin Y  et al. Glycogen synthase kinase 3ß inhibition as a therapeutic approach in the treatment of endometrial cancer. Int J Mol Sci 14:16617-37 (2013). WB . Read more (PubMed: 23941783) »

See 1 Publication for this product

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