Overview

  • Product name
  • Description
    Rabbit polyclonal to GTF2IRD1
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Horse, Cow, Dog, Pig, Chimpanzee, Gorilla, Orangutan
  • Immunogen

    Synthetic peptide corresponding to a region between residue 650 and 700 of human GTF2IRD1 (NP_057412.1).

  • Positive control
    • Human Controls: Ovarian Carcinoma, Prostate Carcinoma and Stomach Adenocarcinoma.

Properties

Applications

Our Abpromise guarantee covers the use of ab84568 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notes
    IHC-P: 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.

    Likely to work with frozen sections

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      May be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation. May repress GTF2I transcriptional functions, by preventing its nuclear residency, or by inhibiting its transcriptional activation. May contribute to slow-twitch fiber type specificity during myogenesis and in regenerating muscles. Binds troponin I slow-muscle fiber enhancer (USE B1). Binds specifically and with high affinity to the EFG sequences derived from the early enhancer of HOXC8.
    • Tissue specificity
      Highly expressed in adult skeletal muscle, heart, fibroblast, bone and fetal tissues. Expressed at lower levels in all other tissues tested.
    • Involvement in disease
      Note=GTF2IRD1 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of GTF2IRD1 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.
    • Sequence similarities
      Belongs to the TFII-I family.
      Contains 5 GTF2I-like repeats.
    • Developmental stage
      Highly expressed in developing and regenerating muscles, at the time of myofiber diversification.
    • Domain
      The N-terminal half may have an activating activity.
    • Cellular localization
      Nucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • CREAM1 antibody
      • General transcription factor II I repeat domain containing protein 1 antibody
      • General transcription factor II-I repeat domain-containing protein 1 antibody
      • General transcription factor III antibody
      • GT2D1_HUMAN antibody
      • GTF2I repeat domain containing protein 1 antibody
      • GTF2I repeat domain-containing protein 1 antibody
      • GTF2IRD1 antibody
      • GTF3 antibody
      • Muscle TFII I repeat domain-containing protein 1 antibody
      • Muscle TFII-I repeat domain-containing protein 1 antibody
      • MUSTRD1 antibody
      • MusTRD1/BEN antibody
      • RBAP2 antibody
      • Slow muscle fiber enhancer binding protein antibody
      • Slow-muscle-fiber enhancer-binding protein antibody
      • USE B1 binding protein antibody
      • USE B1-binding protein antibody
      • WBSCR11 antibody
      • WBSCR12 antibody
      • Williams Beuren syndrome chromosome region 11 protein antibody
      • Williams-Beuren syndrome chromosomal region 11 protein antibody
      • Williams-Beuren syndrome chromosomal region 12 protein antibody
      see all

    Images

    • ab84568, at a 1/500 dilution, staining GTF2IRD1 in formalin fixed, paraffin embedded human prostate carcinoma by Immunohistochemistry, using DAB detection.

    References

    ab84568 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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