Overview

  • Product name
    GTP-γ-S
  • Description
    G-protein-activating GTP analog
  • Biological description
    G-protein-activating GTP analog. More hydrolysis resistant than GTP. Stimulates insulin release from pancreatic β-cells. Inhibits organelle transport along axonal microtubules. Induces exocytosis in vivo.
  • Purity
    > 90%

Properties

  • Molecular weight
    539.24
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C10H16N5O13P3S
  • CAS Number
    94825-44-2
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in water to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:
  • Pepperkok R  et al. Three distinct steps in transport of vesicular stomatitis virus glycoprotein from the ER to the cell surface in vivo with differential sensitivities to GTP gamma S. J Cell Sci 111 ( Pt 13):1877-88 (1998). Read more (PubMed: 9625750) »
  • Bloom GS  et al. GTP gamma S inhibits organelle transport along axonal microtubules. J Cell Biol 120:467-76 (1993). Read more (PubMed: 7678421) »
  • Robinson LJ  et al. Translocation of the glucose transporter (GLUT4) to the cell surface in permeabilized 3T3-L1 adipocytes: effects of ATP insulin, and GTP gamma S and localization of GLUT4 to clathrin lattices. J Cell Biol 117:1181-96 (1992). Read more (PubMed: 1607382) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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