Overview

  • Product name
    GTS-21 dihydrochloride (DMBX-A)
  • Description
    α7 Nicotinic acetylcholine receptor agonist
  • Alternative names
    • DMBX-A
  • Biological description
    Partial agonist at α7nACh receptors. Binds selectively to α7 subunits, with no significant activity seen at α2, α3 and α4. (EC50 = 10 μM in vitro (striatal slices)). Shown to elicit nootropic, neuroprotective and anti-inflammatory effects.
  • Purity
    > 98%

Properties

References

This product has been referenced in:
  • Kox M  et al. a7 nicotinic acetylcholine receptor agonist GTS-21 attenuates ventilator-induced tumour necrosis factor-a production and lung injury. Br J Anaesth 107:559-66 (2011). Read more (PubMed: 21771746) »
  • Stevens KE  et al. Continuous administration of a selective alpha7 nicotinic partial agonist, DMXBA, improves sensory inhibition without causing tachyphylaxis or receptor upregulation in DBA/2 mice. Brain Res 1352:140-6 (2010). Read more (PubMed: 20599427) »
  • Meyer EM  et al. 3-[2,4-Dimethoxybenzylidene]anabaseine (DMXB) selectively activates rat alpha7 receptors and improves memory-related behaviors in a mecamylamine-sensitive manner. Brain Res 768:49-56 (1997). Read more (PubMed: 9369300) »
  • Rosas-Ballina M  et al. The selective alpha7 agonist GTS-21 attenuates cytokine production in human whole blood and human monocytes activated by ligands for TLR2, TLR3, TLR4, TLR9, and RAGE. Mol Med 15:195-202 (0). Read more (PubMed: 19593403) »
  • Briggs CA  et al. Functional characterization of the novel neuronal nicotinic acetylcholine receptor ligand GTS-21 in vitro and in vivo. Pharmacol Biochem Behav 57:231-41 (0). Read more (PubMed: 9164577) »

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