Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesGuinea pig
    • SequenceQEDPNAYSEEFFDV
    • Amino acids232 to 245

Specifications

Our Abpromise guarantee covers the use of ab38200 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • FormLyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

  • ReconstitutionReconstitute with deionized water. (A stock solution of 2mgs/ml is recommended for most absorption control applications.)

General Info

  • Alternative names
    • ADCA
    • Alpha neoendorphin
    • Beta neoendorphin
    • Beta-neoendorphin-dynorphin
    • Big Dyn
    • Big dynorphin
    • Dyn
    • Dyn-A17
    • Dyn-B
    • Dynorphin A
    • Dynorphin A(1-13)
    • Dynorphin A(1-17)
    • Dynorphin A(1-8)
    • Dynorphin B
    • Dynorphin B(1-13)
    • Dynorphin B-29
    • Enkephalin B
    • Leu enkephalin
    • Leumorphin
    • Neoendorphin dynorphin enkephalin prepropeptide
    • PDYN
    • PDYN_HUMAN
    • PENKB
    • Preprodynorphin
    • Preproenkephalin B
    • Prodynorphin
    • Proenkephalin B
    • Rimorphin
    • SCA23
    see all
  • FunctionLeu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
    Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin.
    Leumorphin has a typical opiod activity and may have anti-apoptotic effect.
  • Involvement in diseaseDefects in PDYN are the cause of spinocerebellar ataxia type 23 (SCA23) [MIM:610245]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA23 is an adult-onset autosomal dominant form characterized by slowly progressive gait and limb ataxia, with variable additional features, including peripheral neuropathy and dysarthria.
  • Sequence similaritiesBelongs to the opioid neuropeptide precursor family.
  • Post-translational
    modifications
    The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.
  • Cellular localizationSecreted.
  • Information by UniProt

References for Guinea pig ProDynorphin peptide (ab38200)

ab38200 has not yet been referenced specifically in any publications.

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