Biological descriptionNovel activator of KCa2 ('SK') channels. Selective SK1 channel activator (EC50 = 8.2 μM). First true activator of KCa2.x and KCa3.1 channels; displays 100-fold greater selectivity for KCa2.x over KCa3.1.
Supplied in ethanol (25 mg/ml). Please note this compound is unstable as the solid form and unstable in DMSO
Chemical name4-(2-Methoxyphenylcarbamoyloxymethyl)piperidine-1-carboxylic acid tert-butyl ester
Storage instructionsStore at +4°C (desiccating conditions).
Solubility overviewSupplied in ethanol (25 mg/ml)
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Balut CM et al. Immunofluorescence-based assay to identify modulators of the number of plasma membrane KCa3.1 channels. Future Med Chem2:707-13 (2010).
Read more (PubMed: 20596245) »
Hougaard C et al. Selective activation of the SK1 subtype of human small-conductance Ca2+-activated K+ channels by 4-(2-methoxyphenylcarbamoyloxymethyl)-piperidine-1-carboxylic acid tert-butyl ester (GW542573X) is dependent on serine 293 in the S5 segment. Mol Pharmacol76:569-78 (2009).
Read more (PubMed: 19515965) »