Overview

  • Product nameGYKI 53655 hydrochloride
  • Description
    Non-competitive AMPA / kainate receptor antagonist
  • Alternative names
    • LY300168
  • Biological descriptionNon-competitive AMPA and kainate receptor antagonist. (IC50 values for inhibition of AMPA-mediated responses in cells expressing human GluR1 and GluR4 are 6 and 5 µM, respectively). Analog of GYKI 52466 (ab120336). Anticonvulsant in vivo. At higher concentrations blocks GluK3 homomeric receptors (IC50 = 63 μM) and GluK2b(R)/GluK3 heteroreceptors (IC50 = 32 μM).

    Also available in simple stock solutions (ab144499) - add 1 ml of water to get an exact, ready-to-use concentration.
  • Purity> 99%

Properties

    Associated products

    References for GYKI 53655 hydrochloride (ab120490)

    This product has been referenced in:
    • Szabados T  et al. Comparison of anticonvulsive and acute neuroprotective activity of three 2,3-benzodiazepine compounds, GYKI 52466, GYKI 53405, and GYKI 53655. Brain Res Bull 55:387-91 (2001). Read more (PubMed: 11489346) »
    • Partin KM & Mayer ML Negative allosteric modulation of wild-type and mutant AMPA receptors by GYKI 53655. Mol Pharmacol 49:142-8 (1996). Read more (PubMed: 8569699) »
    • Bleakman D  et al. Activity of 2,3-benzodiazepines at native rat and recombinant human glutamate receptors in vitro: stereospecificity and selectivity profiles. Neuropharmacology 35:1689-702 (1996). Read more (PubMed: 9076748) »

    See all 3 Publications for this product

    Product Wall

    There are currently no Abreviews or Questions for ab120490.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"