Anti-H1N1 Influenza A virus Nucleocapsid protein antibody (ab106485)

Overview

  • Product nameAnti-H1N1 Influenza A virus Nucleocapsid protein antibody
    See all H1N1 Influenza A virus Nucleocapsid protein primary antibodies
  • Description
    Rabbit polyclonal to H1N1 Influenza A virus Nucleocapsid protein
  • Specificityab106485 is specific for the seasonal H1N1 influenza NP and will not recognize the corresponding NP from the seasonal H1N1 influenza (A/Brisbane/97/2007 (H1N1)).
  • Tested applicationsSuitable for: ICC/IFmore details
  • Species reactivity
    Reacts with: Influenza A
  • Immunogen

    Synthetic peptide from the H1N1 Influenza A virus Nucleocapsid protein (ACQ76305).

Properties

Applications

Our Abpromise guarantee covers the use of ab106485 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 20 µg/ml.

Target

  • RelevanceEncapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals and is responsible of the active RNP import into the nucleus through the cellular importin alpha/beta pathway. Later in the infection, nucleus export of RNP are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that the nucleoprotein binds directly exportin-1 (XPO1) and plays an active role in RNP nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmask nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.
  • Cellular localizationVirion. Host nucleus
  • Database links
    • Alternative names
      • NP antibody
      • Nucleocapsid protein antibody
      • Nucleoprotein antibody
      • Protein N antibody

    References for Anti-H1N1 Influenza A virus Nucleocapsid protein antibody (ab106485)

    ab106485 has not yet been referenced specifically in any publications.

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